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KMID : 0923620220220010011
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Immune Network
2022 Volume.22 No. 1 p.11 ~ p.11
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Targeting the Epithelium-Derived Innate Cytokines: From Bench to Bedside
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Ham Jong-Ho
Shin Jae-Woo
Ko Byeong-Cheol
Kim Hye-Young
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Abstract
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When epithelial cells are exposed to potentially threatening external stimuli such as allergens, bacteria, viruses, and helminths, they instantly produce “alarmin” cytokines, namely, IL-33, IL-25, and TSLP. These alarmins alert the immune system about these threats, thereby mobilizing host immune defense mechanisms. Specifically, the alarmins strongly stimulate type-2 immune cells, including eosinophils, mast cells, dendritic cells, type-2 helper T cells, and type-2 innate lymphoid cells. Given that the alarm-raising role of IL-33, IL-25, and TSLP was first detected in allergic and infectious diseases, most studies on alarmins focus on their role in these diseases. However, recent studies suggest that alarmins also have a broad range of effector functions in other pathological conditions, including psoriasis, multiple sclerosis, and cancer. Therefore, this review provides an update on the epithelium-derived cytokines in both allergic and non-allergic diseases. We also review the progress of clinical trials on biological agents that target the alarmins and discuss the therapeutic potential of these agents in non-allergic diseases.
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KEYWORD
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Alarmins, Hypersensitivity, Autoimmune disease, Biological therapy
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